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探讨Ｐ１６／ＭＴＳ１基因蛋白在子宫内膜癌组织及癌旁正常组织的表达及意义。采用免疫组化ＡＢＣ法，对２９例子宫内膜癌组织、癌旁组织中Ｐ１６／ＭＴＳ１基因进行检测。并用ＳＹＳＴＡＴ软件，对Ｐ１６／ＭＴＳ１基因表达与临床病理关系进行分析。结果：２９例子宫内膜癌组织，Ｐ１６／ＭＴＳ１基因蛋白表达率为５１．７２％。高分化癌Ｐ１６／ＭＴＳ１基因阳性表达率高于中低分化癌（Ｐ＜０．０５）。结论：Ｐ１６／ＭＴＳ１基因与子宫内膜癌的发生有关。
To investigate the expression and significance of P16 / MTS1 protein in endometrial carcinoma tissues and adjacent normal tissues. The immunohistochemical ABC method was used to detect the P16 / MTS1 gene in 29 cases of endometrial cancer and adjacent tissues. And SYSTAT software, P16 / MTS1 gene expression and clinicopathological analysis. Results: The expression of P16 / MTS1 protein in 29 cases of endometrial carcinoma was 51.72%. The positive rate of P16 / MTS1 gene in well-differentiated carcinoma was higher than that in moderate-poorly differentiated carcinoma (P <0.05). Conclusion: P16 / MTS1 gene is associated with the occurrence of endometrial cancer.