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目的 探讨内皮素 (ET)和一氧化氮 (NO)在妊高征发病中的作用。方法 采用放射免疫法和硝酸还原酶法检测 31例妊高征患者 (妊高征组 )与 2 7例正常足月妊娠妇女 (正常妊娠组 )的血浆ET和血清NO水平。结果 妊高征组血浆ET水平为 10 5 .78± 2 2 .77ng/L ,明显高于正常妊娠组 (6 8.38± 13.2 3ng/L) (P <0 .0 0 1) ,病情越重 ,其值越高 ;妊高征组血清NO水平为 2 1.96± 13.40 μmol/L ,明显低于正常妊娠组 (86 .76± 2 6 .72 μmol/L) (P <0 .0 0 1) ,病情越重 ,其值越低 ;正常妊娠组ET和NO相关不显著 ,妊高征组ET和NO呈负相关关系 (P <0 .0 1)。结论 ET和NO在妊高征的发病中起重要作用 ,ET/NO比值越大 ,病情越重。
Objective To investigate the role of endothelin (ET) and nitric oxide (NO) in the pathogenesis of PIH. Methods Plasma ET and serum NO levels were measured by radioimmunoassay and nitrate reductase in 31 patients with PIH (pregnancy induced hypertension) and 27 normal pregnant women (normal pregnancy group). Results The plasma ET level in PIH group was 105.78 ± 222.7ng / L, which was significantly higher than that in normal pregnancy group (6.38 ± 13.2 3ng / L) (P0.01) (P <0.01). The serum NO level in PIH group was 2 1.96 ± 13.40 μmol / L, which was significantly lower than that in normal pregnancy group (86.76 ± 26.72 μmol / L) The more severe the disease, the lower its value. The correlation between ET and NO in normal pregnancy group was not significant. There was a negative correlation between ET and NO in PIH (P <0.01). Conclusions ET and NO play an important role in the pathogenesis of PIH. The greater the ET / NO ratio, the more severe the disease.