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目的:探讨血清中脑钠肽(BNP)与蒽环类药物累积量的相关性。方法:收集使用蒽环类药物化疗后的淋巴瘤患者30例,统计患者所用蒽环类药物的累积量,检测患者血清中的BNP值,分析血清中BNP与蒽环类药物累积量的相关性。结果:蒽环类药物累积量为0～950mg,血清中BNP为5～1276pg/ml,蒽环类药物累积量与血清中BNP无线性相关(P>0.05)。结论:不能推荐使用血清中BNP来检测蒽环类药物心脏毒性累积的严重程度。
Objective: To investigate the correlation between serum brain natriuretic peptide (BNP) and anthracycline accumulation. Methods: Totally 30 patients with lymphoma after anthracycline chemotherapy were collected. The cumulative amount of anthracycline used in patients was collected. The serum BNP level was measured. The correlation between serum BNP and anthracycline accumulation . Results: The accumulative amount of anthracycline was 0 ~ 950mg and the serum BNP was 5 ~ 1276pg / ml. Anthracycline accumulation correlated with the non-linearity of serum BNP (P> 0.05). CONCLUSION: BNP in serum can not be recommended for detecting the severity of anthracycline cardiotoxicity accumulation.