[Objective] To study the effects of clindamycin on germ cells of male mice. [Method] A total of 48 healthy adult male mice were randomly divided into group A, group B, group C and control group, 12 mice in each group. The mice in the group A, group B and group C were respectively administrated with clindamycin at doses of 15, 30 and 60 mg/kg·d via intraperitoneal injection, and those in the control group were treated with normal saline. On Day 29 after administration, the mice were killed by dislocation, and the sperm motility rate, sperm deformity rate and the percentage of sperm having swollen tail membrane were determined, respectively. [Result] The sperm motility rate and the percentage of sperm having swollen tail membrane of the group B and group C were lower than those of the control group; and the sperm deformity rate of the group B and group C was higher than that of the control group. The sperm motility rate, sperm deformity rate and percentage of sperm having swollen tail membrane had no significant difference between the group A and control group. [Conclusion] The clindamycin at a dose equal to or more than that used for severe infection affects the normal function of sperm in mice. [Objective] To study the effects of clindamycin on germ cells of male mice. [Method] A total of 48 healthy adult male mice were randomly divided into groups A, group B, group C and control group, 12 mice in each group. mice in the group A, group B and group C were respectively administrated with clindamycin at doses of 15, 30 and 60 mg / kg · d via intraperitoneal injection, and those in the control group were treated with normal saline. On Day 29 after administration , the mice were killed by dislocation, and the sperm motility rate, sperm deformity rate and the percentage of sperm having swollen tail membrane were determined, respectively. [Result] The sperm motility rate and the percentage of sperm having swollen tail membrane of the group B and group C were lower than those of the control group; and the sperm deformity rate of the group B and group C was higher than that of the control group. The sperm motility rate, sperm deformity rate and percentage of sperm having swollen tail m embrane had no significant difference between the group A and control group. [Conclusion] The clindamycin at a dose equal to or more than that used for severe infection affects the normal function of sperm in mice.