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目的:调查某院肝炎或肝硬化患者质子泵抑制药的使用情况,并进行合理性评价。方法:对某院2013~2014年诊断为“肝炎”或“肝硬化”的住院患者质子泵抑制药的应用情况进行回顾性分析,并对使用合理性进行评价。结果:共收集到211份病历,使用质子泵抑制药192例,使用率91%;不合理用药62例,占总病例数的29.3%;用药不合理主要表现为用药疗程过长(24.5%),预防用药指征不充分(5.7%),无目的用药(2.6%)。结论:肝炎或肝硬化患者质子泵抑制药的不合理使用十分普遍,临床药师应加强药学监护,促进合理用药。
Objective: To investigate the use of proton pump inhibitors in patients with hepatitis or cirrhosis in a hospital and evaluate their rationality. Methods: The clinical data of hospitalized patients with proton pump inhibitor diagnosed as “hepatitis” or “cirrhosis” from 2013 to 2014 were analyzed retrospectively and the rationality was evaluated. Results: A total of 211 medical records were collected and 192 cases were treated with proton pump inhibitors, with a utilization rate of 91%. Sixty-two unreasonable doses accounted for 29.3% of the total number of cases. Irrational medication was mainly manifested as long medication duration (24.5%), , Inadequate indication of prophylaxis (5.7%), and no intentional medication (2.6%). Conclusion: Unreasonable use of proton pump inhibitors in patients with hepatitis or cirrhosis is very common. Clinical pharmacists should strengthen their medical supervision and promote the rational use of drugs.