弓形虫可侵袭哺乳动物的各个器官,生殖系统也不例外。弓形虫感染睾丸可致支持细胞、间质细胞以及各级生精细胞的损伤,激素分泌的异常,精子出现畸形等,从而导致雄性生殖障碍。弓形虫作为一种可致男性不育的潜在致病原,已引起广泛的重视。弓形虫可直接损害睾丸细胞,或通过细胞因子,一氧化氮(NO)异常导致睾丸细胞的激素分泌异常,凋亡增加。总之,弓形虫可通过多种途径导致睾丸的损伤。本文对国内外有关弓形虫致睾丸细胞损伤机制的研究资料作一简要综述。 Toxoplasma gondii can invade various mammalian organs, the reproductive system is no exception. Toxoplasma gondii infection testicular can cause supportive cells, interstitial cells and spermatogenic cells at all levels of injury, abnormal hormone secretion, sperm deformity, resulting in male reproductive disorders. Toxoplasma gondii, as a potential causative agent of male infertility, has attracted a great deal of attention. Toxoplasma gondii can directly damage the testicular cells, or through abnormal cytokines, nitric oxide (NO) lead to abnormal hormone secretion testicular cells, increased apoptosis. In summary, Toxoplasma can cause testicular damage through a variety of pathways. This article gives a brief overview of the research data on the mechanism of testicular cell damage induced by Toxoplasma gondii at home and abroad.