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目的分析β-内酰胺类抗菌药物不良反应(ADR)发生的特点,为临床合理用药提供参考。方法采用回顾性调查方法对本院2005～2008年度收集到的125份β-内酰胺类抗菌药物不良反应报告进行统计学分析,归纳总结出β-内酰胺类抗菌药物不良反应发生一般规律和有关特征。结果4年间共收到181份ADR报告,其中由β-内酰胺类抗菌药物引起的ADR125例占69.06%,病例报告中涉及18种β-内酰胺类抗菌药物,主要为头孢曲松钠(24例)、青霉素钠(20例)和头孢噻肟钠(13例)。ADR累及人体的14个系统,表现以皮肤及附件损伤最为常见,其次为心血管系统、消化系统等。结论应合理使用β-内酰胺类抗菌药物,重视ADR的监测工作,避免和减少ADR的发生。
Objective To analyze the characteristics of adverse reactions of β-lactam antibiotics (ADRs) and provide references for clinical rational drug use. Methods A retrospective survey of 125 cases of β-lactam antibiotics collected in our hospital from 2005 to 2008 were collected for statistical analysis. The general rules of adverse reactions of β-lactam antibiotics were summarized. feature. RESULTS: A total of 181 ADRs were reported over a 4-year period, with 125 cases of ADR caused by β-lactam antibiotics (69.06%) and 18 cases of β-lactam antibiotics, mainly ceftriaxone sodium (24 Cases), penicillin sodium (20 cases) and cefotaxime sodium (13 cases). ADR involving the body’s 14 systems, the performance of the skin and accessories damage the most common, followed by the cardiovascular system, digestive system. Conclusion The β-lactam antibiotics should be used rationally and monitoring of ADR should be emphasized to prevent and reduce the occurrence of ADR.