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[目的]观察疏肝潜阳汤联合西药治疗肝郁火旺型甲亢合并房颤疗效。[方法]使用随机平行对照方法,将69例住院患者按抛硬币法简单随机分为两组。对照组35例倍他乐克,50mg/次,3次/d;丙基硫氧嘧啶,首剂100mg/次,3次/d,逐月减至50mg/d;丙基硫氧嘧啶不耐受改为他巴唑,首剂10mg/次,3次/d,逐月减至5mg/d。治疗组34例疏肝潜阳汤(麦冬、天冬15g,郁金、香附、钩藤、白蒺藜各12g,生龙骨~(先煎)、生牡蛎~(先煎)各30g,牡丹皮、丹参、赤芍、白芍、贝母、天竺黄各10g),大枣6枚,1剂/d,水煎400mL,早晚口服,200mL/次;西药治疗同对照组。连续治疗90d为1疗程。观测临床症状、FT3、FT4、TSH、不良反应。治疗1疗程,判定疗效。[结果]治疗组痊愈25例,显效5例,有效2例,无效2例,总有效率94.12%。对照组痊愈5例,显效13例,有效3例,无效14例,总有效率60.00%。治疗组疗效优于对照组(P<0.01)。甲状腺功能指标大部分有改善(P<0.01),对照组FT3无改善(P>0.05),治疗组改善大部分优于对照组(P<0.01),FT3两组无明显差异(P>0.05)。严重等级两组均有降低(P<0.01),治疗组降低高于对照组(P<0.01)。[结论]疏肝潜阳汤联合西药治疗肝郁火旺型甲亢合并房颤疗效满意,无不良反应,值得推广。
[Objective] To observe the curative effect of Shugan Qiangyang Decoction combined with western medicine in treatment of hyperthyroidism with liver depression and fire-wang hyperthyroidism complicated with atrial fibrillation. [Methods] Using randomized parallel control method, 69 inpatients were randomly divided into two groups according to the coin-tossing method. In the control group, 35 patients received metoprolol, 50mg / time, 3 times / d, propylthiouracil, the first dose of 100mg / time, 3 times / d, monthly reduced to 50mg / d; propylthiouracil intolerance Subject to methimazole, the first dose of 10mg / time, 3 times / d, monthly reduced to 5mg / d. In the treatment group, 34 cases of Shuganqiangyang decoction (Radix Ophiopogonis, asparagus 15g, turmeric, Cyperus rotundus, Uncaria, Tribulus terrestris each 12g, raw keel ~ (first fried), raw oysters ~ Radix Paeoniae Alba, peony root, Radix Paeoniae Alba, Radix Paeoniae Alba, Radix Paeoniae Alba, Radix Paeoniae Alba, Radix Paeoniae Alba, peony root, Radix Paeoniae Alba, Radix Paeoniae Alba, peony root, Continuous treatment of 90d for a course of treatment. Observed clinical symptoms, FT3, FT4, TSH, adverse reactions. Treatment of a course of treatment to determine the efficacy. [Results] The treatment group recovered 25 cases, 5 cases markedly effective, 2 cases effective, 2 cases ineffective, the total effective rate was 94.12%. The control group recovered in 5 cases, markedly effective in 13 cases, effective in 3 cases, ineffective in 14 cases, the total effective rate was 60.00%. The treatment group than the control group (P <0.01). Most of the thyroid function indexes were improved (P <0.01), FT3 of the control group had no improvement (P> 0.05), most of the improvement in the treatment group was better than that of the control group (P <0.01) . The severity was lower in both groups (P <0.01), and the treatment group was lower than the control group (P <0.01). [Conclusion] Shugan qi yang decoction combined with western medicine has satisfactory curative effect on hyperthyroidism with hyperthyroidism and atrial fibrillation, no adverse reactions, and worthy of promotion.