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目的 :观察复方丹参注射液对硝酸甘油 (NTG)控制性降压时动脉血气改变的影响。方法 :1 6例在全身麻醉、控制性降压下择期手术的成人患者 ,随机分成对照组与丹参组(各 8例 )。两组均用NTG控制性降压 ,血压下降幅度约为对照值的 3 0 % ,丹参组在降压前静脉注射复方丹参注射液 1 6ml。结果 :对照组在降压期间动脉血氧分压 (PaO2 )显著下降 ,动脉血于呼气末二氧化碳分压差 (Pa etCO2 )显著升高 ,而丹参组血气无显著性改变。结论 :复方丹参注射液可预防NTG对血气的不良影响。
Objective : To observe the effects of Compound Danshen Injection on arterial blood gas changes during nitroglycerin (NTG) controlled hypotensive. Methods: Sixteen adult patients undergoing selective surgery under general anesthesia and controlled hypotension were randomly divided into control group and Salvia miltiorrhiza group (8 cases each). Both groups were controlled by NTG blood pressure, blood pressure decreased by about 30% of the control value, Danshen group before intravenous antihypertensive injection of compound Danshen injection 1 6ml. RESULTS: In the control group, arterial oxygen partial pressure (PaO2) decreased significantly during arterial pressure reduction, and arterial blood pressure (Pa etCO2) increased significantly at the end of expiration. There was no significant change in blood gas of the Salvia miltiorrhiza group. Conclusion : Compound Salvia miltiorrhiza injection can prevent adverse effects of NTG on blood gas.