目的 :探讨 IL 18在急性心肌梗死 (AMI)中改变的意义。方法 :用酶联免疫吸附双抗体夹心法动态检测 4 4例 AMI患者和 2 0例健康对照者的血清 IL 18含量 ,分析 IL 18与梗死部分、面积积分、临床积分、血清肌酸激酶同工酶 (CK MB)之间的相关性。结果 :AMI患者血清 IL 18含量明显升高 ,第 2 d达高峰 ,以后开始下降 ,第 14 d接近正常对照组 ;且 IL 18含量变化与血清 CK MB含量变化、临床积分、梗死面积均呈明显的正相关性 (P均 <0 .0 5 ) ;死亡组 IL 18含量明显高于存活组 (P<0 .0 5 )。结论 :IL 18含量与 AMI患者的病情变化相一致 ,其可能参与了 AMI的病理生理过程 ,可作为 AMI患者病情监测和预后的参考指标之一。 Objective: To investigate the significance of IL 18 in acute myocardial infarction (AMI). Methods: Serum IL-18 levels of 44 patients with AMI and 20 healthy controls were detected by enzyme-linked immunosorbent assay (ELISA) double antibody sandwich method. The correlation between IL-18 and infarction, area, clinical score, serum creatine kinase Enzyme (CK MB) between the correlation. Results: Serum levels of IL-18 in patients with AMI were significantly increased and peaked on the second day, then began to decrease, and reached the level of the control group on the 14th day. The changes of IL-18 and serum CK-MB, clinical scores and infarct size were all significant (P <0.05). The level of IL 18 in the death group was significantly higher than that in the survival group (P <0.05). Conclusion: IL 18 content is consistent with the changes of AMI patients’ condition, which may be involved in the pathophysiological process of AMI. It may be used as a reference index for monitoring and prognosis of AMI patients.