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目的 :探讨胃癌微卫星不稳定性 (MSI)与胃腺癌中血管内皮生长因子 (VEGF)之间的关系。方法 :应用PCR SSCP技术检测 30例胃腺癌 5个位点的微卫星不稳定性 ,同时应用免疫组织化学的方法检测肿瘤血管内皮生长因子 (VEGF)蛋白的表达。结果 :MSI阳性率为 4 3.4 % (13 30 )。VEGF阳性率为 6 0 % (18 30 )。MSI H胃癌VEGF的表达显著减少。结论 :MSI H的胃癌与MSS胃癌可能存在两种不同的胃癌及肿瘤血管新生形成的途径。MSI H肿瘤较低的VEGF表达可能可以解释为何MSI H胃癌有较低的侵袭性
Objective: To investigate the relationship between gastric cancer microsatellite instability (MSI) and vascular endothelial growth factor (VEGF) in gastric adenocarcinoma. Methods: PCR SSCP was used to detect the microsatellite instability of 30 gastric adenocarcinoma tissues. Immunohistochemistry was used to detect the expression of vascular endothelial growth factor (VEGF) protein. Results: The positive rate of MSI was 43.4% (13 30). The positive rate of VEGF was 60% (18 30). MSI H gastric cancer VEGF expression was significantly reduced. Conclusion: There are two different pathways of gastric cancer and tumor angiogenesis in MSI H gastric cancer and MSS gastric cancer. Lower VEGF expression in MSI H tumors may explain why MSI H gastric cancer has lower invasiveness