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包含DNA和DNA抗体的免疫复合物在狼疮性肾炎的发病中起重要作用.本文作者新近引用固相放射免疫测定法,对11例活动性SLE肾炎病人,测定了血清中结合DNA的免疫球蛋白,即IgM、IgG、IgA抗DNA抗体水平,并都作了肾活检,藉以探讨狼疮性肾炎肾脏组织病理学与抗DNA免疫球蛋白类别之间的关系.作者认为,用该法测定抗DNA抗体,与常规应用的方法比较,有二大优点:一是能测定抗体的绝对量;二是能区别抗体的免疫球蛋白类别.病例选择的标准为:(1)至少有美国风湿病协
Immunocomplexes containing DNA and DNA antibodies play an important role in the pathogenesis of lupus nephritis.The authors recently cited solid-phase radioimmunoassay in 11 patients with active SLE nephritis and measured serum binding to DNA immunoglobulins , That is IgM, IgG, IgA anti-DNA antibody levels, and have done a kidney biopsy in order to explore the relationship between renal histopathology and anti-DNA immunoglobulin types in patients with lupus nephritis.The authors believe that the use of this method to determine anti-DNA antibodies , Compared with the conventional method, there are two advantages: First, to determine the absolute amount of antibody; second is to distinguish the antibody immunoglobulin categories. Criteria for case selection: (1) at least the United States Association for the treatment of rheumatoid arthritis