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目的研究黑乳海参Holothuria nobilis的化学成分。方法应用多种色谱技术对黑乳海参的化学成分进行分离纯化,根据化合物的理化性质和波谱数据鉴定结构。结果分离得到了2个三萜皂苷元类化合物,应用化学方法和各种光谱技术鉴定其结构为3-O-{3’’’’-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃葡萄糖-(1→4)-β-D-吡喃奎诺糖-(1→2)-4′-O-磺酸钠-β-D-吡喃木糖}-海参烷-22,25-环氧-9-烯-3β,12α,17α,25β-四醇(1)和3-O-{β-D-吡喃奎诺糖-(1→2)-4′-O-磺酸钠-β-D-吡喃木糖}-海参烷-9-烯-18,16-内酯环-22,25环氧-3β,12α,17α-三醇(2)。结论 2个化合物均为新化合物,命名为黑乳海参苷I(nobiliside I,1)和黑乳海参苷II(nobiliside II,2)。
Objective To study the chemical constituents of Holothuria nobilis. Methods A variety of chromatographic techniques were used to separate and purify the constituents of black sea cucumber. The structures were identified based on the physicochemical properties and spectral data of the compounds. Results Two triterpene saponins were isolated and identified as 3-O- {3 ’"- O-methyl-β-D-glucopyranosyl- 1 → 3) -β-D-glucopyranosyl- (1 → 4) -β-D-quinovopyranoso- (1 → 2) -4’- Xylose-sea cucumber-22,25-epoxy-9-ene-3β, 12α, 17α, 25β-tetrol (1) and 3-O- {β-D- 2) sodium 4’-O-sulfo-β-D-xylopyranose} -saturated alkane-9-ene-18,16-lactone ring -22,25 epoxy-3β, 12α, 17α- Alcohol (2). Conclusion Both compounds are novel compounds named nobiliside I and nobiliside II.