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目的 :观察大豆蛋白对实验性急性放射性肠炎的治疗作用。方法 :SD大鼠复制急性放射性肠炎动物模型 ,给予含大豆蛋白饲料 ,检测脏体比、细菌易位率、血清内毒素 ,光镜和扫描电镜观察肠粘膜细胞增生 ,检测血清氨基酸、尿 L/ M比值、肠内容物细菌 S- Ig A包被率等。结果 :使用大豆蛋白后细菌易位率显著降低 ,血 L PS含量不升高 ,回肠绒毛高度、肠全层厚度和粘膜厚度均高于对照组 ,肠粘膜细胞增生好于对照组 ,血清谷氨酰胺和支链氨基酸含量均显著高于对照组 ,L/ M比值、肠内容物细菌 S- Ig A包被率均低于对照组。 结论 :大豆蛋白对实验性急性放射性肠炎有明显的治疗作用 ,可以对抗辐射对肠屏障功能的损害。
Objective: To observe the therapeutic effect of soybean protein on experimental acute radiation enteritis. Methods: The animal model of acute radiation enteritis was duplicated in SD rats, and the intestinal mucosal cell proliferation was observed with the feed containing soy protein, the ratio of viscera, bacterial translocation, endotoxin, light microscope and scanning electron microscope. Serum amino acids and urinary L / M ratio, enteric bacteria S-Ig A coating rate and the like. Results: The bacterial translocation rate was significantly decreased, the content of blood LPS was not increased, the ileum villi height, intestinal full thickness and mucosal thickness were higher than those of the control group, the proliferation of intestinal mucosa was better than that of the control group, Amide and branched chain amino acid content were significantly higher than the control group, L / M ratio, intestinal bacteria content of S-Ig A coating were lower than the control group. Conclusion: Soy protein has a significant therapeutic effect on experimental acute radiation enteritis and can resist the damage of gut barrier function by radiation.