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目的：观察格雷西隆（ｇｒａｎｉｓｅｔｒｏｎ，Ｇｒａ）在造血系统恶性肿瘤化学疗法（化疗）中的止吐作用。方法：４１例造血系统恶性肿瘤病人，于每个疗程用化疗药物前３０ｍｉｎ给Ｇｒａ１支（３ｍｇ）于４０ｍＬ生理盐水中ｉｖ缓慢注射。其中１５例在前１－３个疗程的化疗中，单用甲氧氯普胺作为止吐剂，１０－２０ｍｇ，ｂｉｄ，ｉｍ或ｉｖ，连续５－７ｄ直至化疗结束，其后的１－２个疗程改用Ｇｒａ止吐，用法同上，并作２药止吐作用的Ｒｉｄｉｔ检验。结果：用Ｇｒａ后，在化疗中的病人无呕吐例次占８０％，每天呕吐１－２次的例次占１６％，总有效率９６％；用甲氧氯普胺的化疗中病人无呕吐例次占９％，每天呕吐１－２次的例次占９％，总有效率１８％。结论：格雷西隆能有效地控制造血系统恶性肿瘤病人因化疗引起的呕吐。
OBJECTIVE: To observe the antiemetic effects of granisetron (Gra) in chemotherapy (chemotherapy) of hematopoietic malignancy. Methods: Forty-one patients with hematopoietic malignancies were given iv injections of Gra1 (3 mg) in 40 mL physiological saline 30 min before each course of chemotherapy. Fifteen of them received metoclopramide as an antiemetic, 10-20 mg, bid, im or iv for the first 1-3 cycles of chemotherapy, and continued for 5-7 days until the end of chemotherapy, followed by 1-2 The course of treatment was changed to Gra, antiemetic, usage ibid, and Ridit test for antiemetic effect of 2 drugs. Results: After Gra was used, 80% of the patients had no vomiting during chemotherapy, 16% had vomiting 1-2 times per day, and the total effective rate was 96%; patients who received chemotherapy with metoclopramide did not vomit Cases accounted for 9% of cases, vomiting 1-2 times a day accounted for 9% of cases, the total efficiency of 18%. CONCLUSION: Grycilone can effectively control vomiting caused by chemotherapy in patients with hematopoietic malignancy.