论文部分内容阅读
观察了心得安对肾综合征出血热（HFRS）的疗效，研究了该药对患者肾脏血液动力学的影响，检测了血浆血管紧张素-Ⅱ（AT-Ⅱ）和尿素氮（BUN），部分患者还作了肾脏B超和ECT检查。结果：心得安治疗组少尿期血浆AT-Ⅱ和BUN水平均低于对照组，（分别为290．2±51．3ng／LVs338．5±84．2ng／L，P＜0．05；和25．2±9．7mmol／L，Vs33．8±11．lmmol／L，P＜0．05），多尿持续时间明显短于对照组（7．5±4．4天，VS11．3±5．8天，P＜0．05），尿蛋白消失时间亦显著快于对照组（7．5±3．7天Vs10．8±4．2天，P＜0．05）。B超显示治疗组肾肿胀程度明显轻于对照组，ECT提示治疗组肾小球滤过率（GFR）和有效肾血浆流量（ERPF）均高于对照组。以上资料表明心得安对HFRS有良好疗效。
The effect of propranolol on hemorrhagic fever with renal syndrome (HFRS) was observed. The effect of propranolol on renal hemodynamics of the patients was studied. Plasma levels of angiotensin-Ⅱ (AT-Ⅱ) and urea nitrogen (BUN) The patient also made a kidney B ultrasound and ECT examination. Results: The levels of plasma AT-Ⅱ and BUN in the experimental group were lower than those in the control group (290.2 ± 51.3ng / LVs, respectively, 338.5 ± 84.2ng / L, P <0.05) 25.2 ± 9.7mmol / L, Vs33.8 ± 11.lmmol / L, P <0.05), duration of polyuria was significantly shorter than that of the control group (7.5 ± 4.4 days, VS11.3 ± 5.8 days, P <0.05). The disappearance time of urinary protein was also significantly faster than that of the control group (7.5 ± 3.7 days Vs10.8 ± 4.2 days, P <0.05). B-ultrasound showed that the degree of renal swelling in the treatment group was significantly lower than that in the control group. The ECT indicated that the GFR and ERPF in the treatment group were higher than those in the control group. The above data show that propranolol has a good effect on HFRS.