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弥漫性血管内凝血(Disseminated Intra-vascular Coagulation,DIC)是临床各科均可见的严重微循环障碍性并发症。近年来发现血小板功能和前列腺素代谢与止血、血栓性疾病的发生有着密切关系。尤其是血小板产生的 TXA_2和血管内皮细胞产生的 PGI_2的平衡在保持机体内环境稳定方面起着重要的作用。本文旨在建立比较合理的急性 DIG 动物模型基础上较全面地动态观察急性 DIC形成过程中体内凝血因子、血小板功能、前列腺素代谢及微循环状态的变化和病理的改变,客观地探讨山莨菪碱对于 DIC 的防治作用。
Disseminated Intra-vascular Coagulation (DIC) is a serious complication of microcirculation that can be seen in all clinical departments. In recent years, we found that platelet function and prostaglandin metabolism and hemostasis, thrombotic diseases are closely related. In particular, the balance of TXA 2 produced by platelets and PGI 2 produced by vascular endothelial cells plays an important role in maintaining the homeostasis of the body. This paper aims to establish a more reasonable animal model of acute DIG based on a more comprehensive dynamic observation of acute DIC in the process of formation of coagulation factors, platelet function, prostaglandin metabolism and microcirculation state changes and pathological changes, an objective study of anisodamine For the prevention and treatment of DIC.