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目的：探讨我院抗生素的临床应用相关情况，同时对相关临床细菌耐药性的情况进行分析。方法选择2013年1月～2015年1月期间我院收治的210例感染患者中200例应用抗生素的情况进行分析，同时统计分析患者使用抗生素的种类、药物敏感试验、菌种对抗生素的耐药性等情况。结果本次调查抗生素平均应用时间在1.6～43d，使用两种抗生素的患者为103例（51.50%），使用3种的患者为35例（17.50%），4种的患者19例（9.50%）；1种的患者43例（21.50%）。结论临床上应该依据药敏试验结果来合理选择抗菌药物，能够在一定程度上避免滥用药物的情况发生，此外，也能够为临床医生正确合理应用抗生素，降低耐药菌株的产生、预防医院感染提供参考依据。“,”Objective To discuss the situation of use of antibiotics and bacterial resistance analysis of our hospital, so as to guide rational use of drugs. Methods A total of 210 cases of infected patients in our hospital from Jan 2013 to Jan 2015 were selected as research subjects, their application of antibiotics were analyzed, and the kinds of antibiotics, drug sensitivity test and the drug resistance were discussed. Results The average time of antibiotics were 1.6 to 34 days, the patients use two kinds of antibiotics were 103 cases (51.50%), three kinds of antibiotics were 35 cases(17.50%), four kinds of antibiotics were 19 cases(9.50%) and single antibiotics were 43 cases(21.50%). Conclusion The choice of antibiotic use in clinical based on drug sensitive test can avoid drug abuse somehow, and can provide scientific proof for properly using antibiotics, reducing the resistant strains and preventing nosocomial infection.