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利血平是一具有肾上腺素能活性的药物,用作肾上腺素能拮抗物。在评价该化合物是否干扰人的受精过程,作为一个有希望的杀精子避孕药时,作者对各种浓度的利血平(2×10~(-6),2×10~(-7),2×10~(-8),2×10~(-9),以及2×10~(-10)M)对人精子体外受精的影响进行了研究。作者从有生育力的男子采集精子,用BWW培养基洗涤,再和不同浓度的利血平一起培育5小时,然后进行金黄田鼠去透明带卵的穿透试验。6小时后记录精子穿透情况并进行统计分析。实验结果表明,与对照组比较,各种浓度的利血平均有明显的抑制受精作用。对照组的金黄田鼠去透明带卵的穿透率为
Reserpine is an adrenergic drug used as an adrenergic antagonist. In assessing whether this compound interferes with human fertilization, as a promising contraceptive for spermatogenesis, the authors evaluated the effects of various concentrations of reserpine (2 × 10 -6, 2 × 10 -7, 2 × 10 -8, 2 × 10 -9, and 2 × 10 -10 M) on the in vitro fertilization of human sperm were studied. The authors collected sperm from fertile men, washed them with BWW medium, and incubated with different concentrations of reserpine for 5 hours before performing the penetrating test of the golden vole for zona pellucida eggs. Six hours later, sperm penetration was recorded and analyzed statistically. The experimental results show that, compared with the control group, various concentrations of reserpine have significant inhibitory effect on fertilization. The control group of golden vole to the zona pellucida egg penetration rate