论文部分内容阅读
目的 探讨儿童恙虫病的脑损害特点及治疗和预后情况。方法 回顾收治的 2 5 3例儿童恙虫病 ,对以脑部症状为主要表现的 19例 ( 7 5 % )进行临床分析 ,比较急性期、恢复期脑脊液、脑电图及头颅CT变化 ,用氯霉素按 5 0mg/(kg·d)静滴治疗。结果 ①儿童恙虫病脑损害的脑脊液呈非化脓性改变 ,蛋白定量及细胞计数多为轻度增高 ,细胞分类以单核为主 ;②急性期脑电图异常率 10 0 % ,头颅CT异常率 4 7 1% ,治疗 2周复查 ,脑电图及CT异常基本恢复 ;③氯霉素治疗 7～ 10d脑部症状体征基本消失。结论 儿童恙虫病脑损害临床过程及脑脊液改变与病毒性脑炎相似 ,氯霉素对该病有特效
Objective To investigate the characteristics of brain damage and treatment and prognosis of scrub typhus in children. Methods Twenty-five cases of scrub typhus were retrospectively reviewed. Nineteen patients (75%) with brain symptoms were analyzed clinically. Cerebrospinal fluid (CSF), electroencephalogram (EEG) and cranial CT were compared during acute phase and convalescent phase. ADM was treated with 50 mg / (kg · d) intravenously. Results ① Cerebrospinal fluid of children with orchitis tsutsugamushi lesions showed non-suppurative changes. The protein quantitation and cell count were slightly increased, while the cell types were mainly mononuclear. ② The abnormal rate of EEG in acute period was 100% and the abnormal rate of CT 4 7 1%, 2 weeks of treatment for review, EEG and CT abnormalities basically recovered; ③ chloramphenicol 7 ~ 10d brain symptoms and signs basically disappeared. Conclusion The clinical process of brain damage in children with tsutsugamushi disease and cerebrospinal fluid changes similar to viral encephalitis, chloramphenicol has a special effect on the disease