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目的 通过动物实验对醋酸纤维素（ cellulose acetate polymer， CAP）的安全性、有效性和病理反应等方面进行重新估价。方法 CAP栓塞 30只大鼠的右侧颈动脉，在栓塞后 4月内的 7个时间阶段各取 2只栓塞后的血管标本行病理检查。采用静脉移植的方法建立犬动脉瘤模型 15枚，以 CAP栓塞 12枚模型，栓塞后 1周、 2周、 2月行造影复查，并随机抽取 1只动物行病理检查。病理检查方法包括 HE染色、 VIII因子染色和透射电镜扫描 。结果 CAP栓塞动脉瘤模型后，在 2个月的观察期内， 12枚动脉瘤中，只有 5枚动脉瘤完全栓塞或部分栓塞而载瘤动脉通畅； 1枚动脉瘤载瘤动脉的 1个分支狭窄； 1枚动脉瘤栓塞后残腔扩大；有 2枚栓塞后 4 d和 5 d动脉瘤破裂； 3枚 1～ 2周后数字减影血管造影复查发现载瘤动脉闭塞。病理检查发现： CAP引起被栓塞血管组织的急性损伤，包括内皮细胞和基膜破坏、脱落，内弹力层裸露附着血栓，纤维细胞和肌细胞严重变性；栓塞后 2月，血栓和 CAP机化，动脉瘤开口被新生的纤维组织和内皮细胞所代替。 结论 CAP具有急性化学腐蚀作用，严重者可以造成栓塞后动脉瘤模型的破裂。此外， CAP栓塞后可以诱发载瘤动脉狭窄或闭塞。鉴于以上缺陷，在临床使用前应经过更多的调整和改进。
Objective To reevaluate the safety, efficacy and pathological response of cellulose acetate polymer (CAP) through animal experiments. Methods CAP was used to embolize the right carotid artery of 30 rats, and 2 embolized blood vessels were taken for pathological examination at 7 time points within 4 months after embolization. Fifteen canine aneurysms were established by vein graft. 12 models of CAP embolization were established. One week, two weeks and two weeks after embolization were performed angiography review. One animal was randomly selected for pathological examination. Pathological examination methods include HE staining, factor VIII staining and transmission electron microscopy. Results After CAP embolization of the aneurysm model, only 5 aneurysms of 12 aneurysms were completely or partially embolized and the parent artery was unobstructed during the 2-month observation period. One branch of the aneurysm-bearing artery Stenosis; 1 aneurysm embolization after the residual cavity expansion; 2 embolization 4 d and 5 d aneurysm rupture; 3 1 to 2 weeks after digital subtraction angiography findings of the parent artery occlusion. Pathological examination found that: CAP caused acute damage to the embolized vascular tissue, including destruction of endothelial cells and basement membrane, exfoliation, adhesion of thrombus on the endochylema, severe degeneration of fibroblasts and myocytes; 2 months after embolization, Aneurysm openings are replaced by nascent fibrous tissue and endothelial cells. Conclusion CAP has acute chemical corrosion, severe cases can cause rupture of posterior embolization aneurysm model. In addition, CAP embolization can induce stenosis or occlusion of the parent artery. In view of the above shortcomings, more adjustments and improvements should be made before clinical use.