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目的:观察加减阳和汤在肺损伤伴发真菌感染临床治疗中的协同作用。方法:将32例肺损伤伴发真菌感染的患者随机分为两组,对照组15例给予抗真菌等常规综合治疗,治疗组17例辅以加减阳和汤治疗。在服药后比较两组患者服药后7、14d外周血中性粒细胞计数及血、肺泡灌洗液G试验结果等变化。结果:治疗组14d外周血中性粒细胞水平较对照组明显改善(P<0.05)。治疗组患者外周血及肺泡灌洗液的G试验结果转阴例数优于对照组(P<0.05,P<0.01)。结论:临床上运用加减阳和汤治疗肺损伤真菌感染能协同抗真菌药提高疗效。
Objective: To observe the synergistic effects of plus and minus Yanghe decoction in the clinical treatment of lung injury associated with fungal infection. Methods: Thirty-two patients with lung injury and fungal infection were randomly divided into two groups. The control group was given anti-fungal and other conventional combined therapy. The treatment group was supplemented with plus and minus Yang and Tang. After taking the drug, the neutrophil count, blood and alveolar lavage fluid G test results were compared between the two groups after 7 and 14 days. Results: The level of peripheral blood neutrophil in the 14th day of treatment group was significantly improved compared with the control group (P <0.05). G test results of peripheral blood and alveolar lavage fluid in the treatment group were better than those in the control group (P <0.05, P <0.01). Conclusion: The clinical application of plus and minus yang and decoction in the treatment of lung injury fungal infection can improve anti-fungal drug efficacy.