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目的：探讨慢性乙型肝炎病人血清可溶性白细胞介素—２受体（ｓＩＬ—２Ｒ）水平、淋巴细胞膜白细胞介素—２受体（ｍＩＬ—２Ｒ）表达及Ｔ细胞亚群的变化及意义。方法：分别采用双抗体夹心ＥＬＩＳＡ法和碱性磷酸酶抗碱性磷酸酶（ＡＰＡＡＰ）法检测了１０８例慢性乙型肝炎病人血清ｓＩＬ—２Ｒ、ｍＩＬ－２Ｒ表达及Ｔ细胞亚群（ＣＤ４、ＣＤ８）的变化，并与６６例同期健康人进行了对照。结果：慢性乙型肝炎病人ｓＩＬ—２Ｒ、ＣＤ８明显增高，ｍＩＬ—２Ｒ、ＣＤ４、ＣＤ４／ＣＤ８明显降低，与对照组比较差异有极显著性（Ｐ＜０．００１），慢性活动性肝炎（ＣＡＨ）较慢性迁延性肝炎（ＣＰＨ）变化更明显（Ｐ＜０．００１）。结论：ｓＩＬ—２Ｒ水平、ｍＩＬ—２Ｒ表达和Ｔ淋巴细胞亚群的变化与慢性乙型肝炎病人病情及预后有关。
Objective: To investigate the changes of serum soluble interleukin-2 receptor (sIL-2R), the expression of membrane interleukin-2 receptor (mIL-2R) and the change of T lymphocyte subsets in patients with chronic hepatitis B and its significance. Methods: Serum levels of sIL-2R and mIL-2R in 108 patients with chronic hepatitis B were measured by double antibody sandwich ELISA and alkaline phosphatase-resistant alkaline phosphatase (APAAP) assay. T cell subsets (CD4, CD8 ) Changes, and compared with 66 cases of healthy people at the same period. Results: The levels of sIL-2R and CD8 were significantly increased in patients with chronic hepatitis B, the levels of mIL-2R, CD4 and CD4 / CD8 were significantly lower in patients with chronic hepatitis B than those in patients with chronic hepatitis B (P <0.001) ) Had more significant changes than chronic persistent hepatitis (CPH) (P <0.001). Conclusion: The levels of sIL-2R, the expression of mIL-2R and the changes of T lymphocyte subsets are related to the condition and prognosis of chronic hepatitis B patients.