克山病是一种原因不明的地方性心肌病,长期以来缺乏有效的预防药物。根据我室1962年提出的克山病水土缺乏病因设想,于1964年开始了缺硒与克山病关系的研究,经过我室和有关单位的试点与验证,已证明应用亚硒酸钠预防克山病发病具有明显效果。为了探讨硒在克山病病因学和发病学中的作用以及硒预防作用的机理,本文对克山病病区和非病区人群机体硒状态以及饮食硒含量进行了对比分析,并对缺硒与克山病某些流行特点的相关性作了初步探讨。材料和方法 Keshan disease is an endemic cardiomyopathy of unknown cause, and there has been a long history of lack of effective preventive drugs. According to my room 1962 Keshan disease caused by a lack of water and soil causes, in 1964 began a selenium deficiency and Keshan disease research, after my room and the pilot and verification of the relevant units, has proved that the use of sodium selenite prevent grams Hill disease has a significant effect. In order to explore the role of selenium in the etiology and pathogenesis of Keshan disease and the mechanism of selenium prophylaxis, the selenium status and dietary selenium content of Keshan disease and non-ward populations were compared and analyzed. Keshan disease and some of the epidemiological characteristics of a preliminary study. Materials and Method