目的 :研究制定利麻鼻用喷雾剂制备和控制方法 ,并观察其临床疗效。方法 :采用紫外分光光度法和旋光法分别测定利巴韦林和盐酸麻黄碱的含量 ,并对40例患者进行临床疗效观察。结果 :利巴韦林和盐酸麻黄碱的平均回收率分别为100 05 %(RSD=0 50 %)和100 10 %(RSD=0 29 %) ,对病毒性上呼吸道感染的有效率为97 %。结论 :利麻鼻用喷雾剂制备工艺合理 ,性质稳定 ,质控方法可行 ,疗效可靠 ,有推广应用价值。 Objective: To study and formulate the method of preparation and control of nerolimazole spray and to observe the clinical curative effect. Methods: The contents of ribavirin and ephedrine hydrochloride were determined by ultraviolet spectrophotometry and polarimetry respectively. The clinical efficacy of 40 patients was observed. RESULTS: The mean recoveries of ribavirin and ephedrine hydrochloride were 100 05% (RSD = 0 50%) and 100 10% (RSD = 0 29%), respectively, and the rates of viral upper respiratory tract infection were 97% . Conclusion: The preparation method of rhizoma nasal spray is reasonable, the quality is stable, the quality control method is feasible, the curative effect is reliable, and it has the promotion and application value.