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目的：研究α－细辛脑对气管纤毛运动的影响，探讨其祛痰作用机理。方法：采用鸽子在体气管和家兔离体气管试验，设空白、阳性对照组及α－细辛脑高、中、低剂量组，以墨汁走距和运行速率作为气管纤毛运动指标，各试验组与空白对照组进行ｔ检验，比较其组间差异。结果：给浅度麻醉的鸽子静脉注射α－细辛脑３２ｍｇ／ｋｇ、１６ｍｇ／ｋｇ、８ｍｇ／ｋｇ，墨汁走距分别为（１．１７±０．１２）ｃｍ、（１．１５±０．１７）ｃｍ和（１．１３±０．１５）ｃｍ，与对照组（０．９４±０．１６）ｃｍ相比，Ｐ分别为Ｐ＜０．０１，Ｐ＜０．０１，Ｐ＜０．０５，在家兔离体气管试验，α－细辛脑剂量为０．４ｍｇ／Ｌ、４ｍｇ／Ｌ和４０ｍｇ／Ｌ时有增强墨汁运行速率，（Ｐ＜０．０５，Ｐ＜０．０１，Ｐ＜０．０１）。结论：α－细辛脑通过增强气管纤毛运动达到祛痰目的。
Objective: To study the effects of α-Asarone on tracheal cilia movement and to explore the mechanism of its expectorant effect. Methods: Pigeon trachea and rabbit in vitro tracheal tube test, set blank, positive control group and α-asarone brain high, medium and low dose group, with ink walking and running speed as the tracheal cilia movement index, the test Group and blank control group t test, compare the differences between groups. RESULTS: The light anesthetized pigeons were intravenously injected with α-asarone 32mg / kg, 16mg / kg and 8mg / kg respectively, and the distance traveled by ink was (1.17 ± 0.12) cm and (1.15 ± 0. 17) cm and (1.13 ± 0.15) cm, P <0.01, P <0.01, P <0 respectively compared with that of the control group (0.94 ± 0.16) cm. 05). In rabbit tracheal extubation, the ink running rate was enhanced when the asarone dose was 0.4mg / L, 4mg / L and 40mg / L, respectively (P <0.05, P < P <0.01). CONCLUSION: Alpha asarone can achieve expectorant expectation by enhancing tracheal cilia movement.