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目的 :寻求膀胱癌术后复发的有效预防方法。方法 :对行保留膀胱手术治疗的 86例膀胱癌患者 ,术后采用羟基喜树碱 (HCPT)行膀胱灌注治疗 ,并与同期作其他药物灌注者进行比较。结果 :随访 71例 (82 .6 % ) ,除 3例灌注不及 1个疗程者外 ,复发 10例 ,复发率为 14.7% (10 / 6 8) ,优于同期内其他药物灌注的预防效果 ,并发症和副作用极轻。结论 :HCPT灌注预防膀胱癌术后复发有较好的效果和较多的优点 ,毒副作用少而轻 ,明显优于其他灌注药物。今后应对其药代动力学作进一步研究。
Objective: To seek effective prevention of bladder cancer recurrence. Methods: Totally 86 bladder cancer patients who had undergone bladder surgery were treated with HCPT for bladder irrigation and compared with those who received other drugs during the same period. Results: A total of 71 patients (82.6%) were followed up, with the exception of 3 cases with less than 1 course of treatment. The recurrence rate was 14.7% (10/68), which was better than that of other drugs during the same period. Complications and side effects are minimal. Conclusion: HCPT can prevent postoperative recurrence of bladder cancer with better effect and more advantages, less toxic side effects, which is obviously better than other perfusion drugs. Future pharmacokinetics should be further studied.