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目的:观察缬沙坦逆转轻中度原发性高血压左室肥厚的疗效。方法:采用自身对照试验,116例轻中度原发性高血压伴左室肥厚的患者,服用缬沙坦80~160 mg/d,共36周,随访患者血压、超声心动图及不良反应。结果:116例患者治疗后血压明显下降(P<0.05),左心室舒末内径(LVDd)、室间隔厚度(IVST)、心室后壁厚度(PWT)、左室重指数(LVMI)均明显减少(P均<0.01),无明显不良反应。结论:缬沙坦治疗轻中度原发性高血压疗效确切,有效逆转左室肥厚。
Objective: To observe the effect of valsartan on reversing left ventricular hypertrophy in patients with mild to moderate essential hypertension. Methods: A total of 116 patients with mild-to-moderate essential hypertension and left ventricular hypertrophy were enrolled in this study. Patients were given valsartan 80-160 mg / d for 36 weeks. Blood pressure, echocardiography and adverse reactions were followed up. Results: After treatment, the blood pressure of 116 patients was significantly decreased (P <0.05), the left ventricular end-diastolic dimension (LVDd), the thickness of interventricular septum (IVST), the thickness of posterior wall of the ventricle (PWT) and the left ventricular mass index (P <0.01), no obvious adverse reactions. Conclusion: Valsartan is effective in treating mild to moderate essential hypertension and effectively reversing left ventricular hypertrophy.