Gli 转录因子与肿瘤

来源 :中国肿瘤临床 | 被引量 : 0次 | 上传用户：myloft1d

【摘要】

：

Hedgehog(HH)信号通路参与胚胎发育、成人组织再生及修复,且在肿瘤细胞生长及转移过程中发挥重要作用.已有大量研究证实该信号通路的异常激活与多种肿瘤的发生发展密切相关.G

【作者】

：

盛晓琳洪璇

【机构】

：

哈尔滨医科大学附属第三医院内一科,哈尔滨市,150081

【出处】

：

中国肿瘤临床

【发表日期】

：

2012年12期

【关键词】

：

Hedgehog Gli 转录因子肿瘤

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Hedgehog(HH)信号通路参与胚胎发育、成人组织再生及修复,且在肿瘤细胞生长及转移过程中发挥重要作用.已有大量研究证实该信号通路的异常激活与多种肿瘤的发生发展密切相关.Gli是HH通路直接调控靶基因的转录因子,是该通路不同水平激活的最后共同通道,在致瘤过程中起着重要作用.Gli受多通路多因素调节,故抑制Gli靶向性治疗具有非常广阔的前景.本文对Hedgehog-Gli信号通路在恶性肿瘤发生发展中的作用、Gli转录活性的调控及致瘤作用、Gli转录因子的靶向治疗价值等方面的研究进展进行综述.

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Gli 转录因子与肿瘤

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