目的观察治糜康栓工艺改进后对大鼠阴道的刺激性反应。方法各组大鼠分别阴道给予治糜康栓(1 g/kg、0.5 g/kg、0.25 g/kg),隔天一次,给药10天。每天观察动物一般状态、阴道及外阴刺激症状并进行病理学检查。结果治糜康栓阴道给药10天后,阴道及外阴无充血、红斑或水肿以及分泌物异常等刺激现象,病理组织学检查无明显病变。结论治糜康栓大鼠阴道给药无刺激性。 Objective To observe the irritant response to the vagina of rats after the improvement of the cure of Mi-Kang. Methods The rats in each group were treated by vaginal administration of Mi Kangshu (1 g / kg, 0.5 g / kg, 0.25 g / kg) once every other day for 10 days. Daily observation of the general state of animals, vaginal and vulvar irritation and pathological examination. Results Mi Mi Kang suppository vaginal administration 10 days, the vagina and vulva no congestion, erythema or edema and secretion abnormalities and other stimuli, no significant pathological changes. Conclusion Mi Mi Kang suppository vaginal administration non-irritating.