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目的观察氯吡格雷、阿司匹林联合溶栓治疗急性ST段抬高型心肌梗死的临床效果。方法选取在该院治疗的急性ST段抬高型心肌梗死患者76例作为研究对象,将患者随机分为观察组和对照组各38例,观察组给予氯吡格雷、阿司匹林联合溶栓治疗,对照组给予阿司匹林联合溶栓治疗,比较2组临床疗效及治疗过程中心肌梗死、血管性死亡、心绞痛复发情况。结果观察组总有效率为94.7%高于对照组的76.3%,差异有统计学意义(χ2=5.21,P=0.022)。观察组心肌梗死复发2例(5.3%),对照组1例(2.6%),2组复发率比较差异无统计学意义(P>0.05);观察组无血管性死亡患者,对照组患者发生血管性死亡1例(2.6%),2组比较差异无统计学意义(P>0.05);观察组心绞痛复发1例(2.6%),对照组心绞痛复发8例(26.3%),2组比较差异显著(χ2=4.54,P=0.033)。结论氯吡格雷、阿司匹林联合溶栓治疗急性ST段抬高型心肌梗死效果显著,患者临床症状可得到有效改善,可在临床中推广应用。
Objective To observe the clinical effect of clopidogrel and aspirin combined with thrombolysis in the treatment of acute ST-segment elevation myocardial infarction. Methods Seventy-six patients with ST-segment elevation acute myocardial infarction (MI) treated in our hospital were enrolled in this study. Thirty-eight patients were randomized into observation group and control group. Patients in observation group were given clopidogrel and aspirin combined with thrombolytic therapy. Group were given aspirin combined thrombolytic therapy, the clinical efficacy of two groups were compared and myocardial infarction, vascular death, recurrence of angina pectoris. Results The total effective rate in the observation group was 94.7%, which was significantly higher than that in the control group (χ2 = 5.21, P = 0.022). The recurrence rate of myocardial infarction was observed in 2 cases (5.3%) in observation group and in control group (2.6%). There was no significant difference in relapse rate between the two groups (P> 0.05). In the observation group, patients with vascular death and control group developed vascular There was no significant difference between the two groups (P> 0.05). The recurrence rate of angina pectoris in observation group was 1 case (2.6%) and in control group 8 cases (26.3%) were recurrent angina pectoris, the difference was significant (χ2 = 4.54, P = 0.033). Conclusion Clopidogrel and aspirin combined with thrombolytic therapy in acute ST-segment elevation myocardial infarction have a significant effect. Clinical symptoms can be effectively improved and can be widely applied in clinical practice.