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目的观察多西他赛联合DF方案治疗进展期胃癌的疗效及不良反应。方法 40例均接受2周期以上化疗,具体化疗方案:多西他赛60 mg/m2静脉滴注第1天,顺铂DDP 20 mg/m2第1~4天静脉滴注,5-Fu 2.0 g/m2,持续静脉滴注72 h。观察患者肿瘤缓解情况及药物不良反应。结果完全缓解2例(5.0%),部分缓解13例(32.5%),稳定13例(32.5%),进展12例(30.0%),有效率37.5%。主要不良反应为骨髓抑制,外周神经毒性,恶心呕吐等。无治疗相关性死亡。结论多西他赛联合DF方案治疗进展期胃癌有较好近期疗效,不良反应可耐受。
Objective To observe the efficacy and adverse reactions of docetaxel combined with DF regimen in the treatment of advanced gastric cancer. Methods Forty patients received more than two cycles of chemotherapy. The specific chemotherapy regimen was docetaxel 60 mg / m2 on the first day, cisplatin DDP 20 mg / m2 on the first day to the fourth day, 5-Fu 2.0 g / m2, continuous intravenous infusion of 72 h. Observed patients with tumor response and adverse drug reactions. Results The complete remission was achieved in 2 cases (5.0%), partial remission in 13 cases (32.5%), stabilization in 13 cases (32.5%), progression in 12 cases (30.0%) and effective rate of 37.5%. The main adverse reactions were myelosuppression, peripheral neurotoxicity, nausea and vomiting. No treatment-related deaths. Conclusions Docetaxel combined with DF regimen has better efficacy in the treatment of advanced gastric cancer and adverse reactions are tolerable.