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目的 研究奥美拉唑 (奥克 )和泰胃美三联疗法治疗幽门螺杆菌 (HP)相关性十二指肠溃疡的愈合率、HP根除率、主要症状缓解率及其安全性。方法 经胃镜证实的十二指肠溃疡患者采用随机抽样、配对分组法分为奥克三联组 (A组 )和泰胃美三联组 (B组 ) ;2周为一疗程 ,停药 4周后复查胃镜。结果 溃疡愈合率 A组为90 .9% ,B组为 42 .1% ,有极显著性差异 P<0 .0 0 1。HP根除率 A组为 86 .4% ,B组为 78.9% ,P>0 .0 5 ,无显著性差异。1周疼痛、烧心和反酸缓解率 A、B两组均有显著性差异。结论 奥克 2周三联疗法对十二指肠溃疡的疗效及症状缓解率明显优于泰胃美 ,而根除 HP无明显差异。
Objective To study the healing rate, HP eradication rate, main symptom remission rate and safety of omeprazole (OEC) and tylosin triple therapy in the treatment of Helicobacter pylori associated duodenal ulcer. Methods The patients with duodenal ulcer confirmed by gastroscope were randomly divided into three groups: group A (triple A) and group T; group A (group B) Review gastroscopy. Results The healing rate of ulcer was 90.9% in group A and 42.1% in group B, with a significant difference P <0.01. HP eradication rate of 86.4% in group A, 78.9% in group B, P> 0.05, no significant difference. 1 week pain, heartburn and acid reflux rate A, B were significantly different between the two groups. Conclusions Ork 2 weeks triple therapy for duodenal ulcer efficacy and symptom relief rate was significantly better than Tai Weimei, and eradication of HP no significant difference.