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建立了用ELISA检测巨细胞病毒(HCMV)IgA抗体的方法,並用于检测北京地区100对母婴的HCMV抗体,母血、脐带血、母乳中HCMV-IgG抗体的阳性率分别为83％,75％和38％,HCMV-IgA抗体的阳性率分别为19％,15％和58％,对其中的16名婴儿半年后追踪观察,5名出生时母、脐血全为阴性的,有2名抗体阳转。8名出生时母、脐血均阳性的,有1名IgA仍阳性並检查发现肝大肋下二指。另1名IgG持续阳性,其他6名婴儿抗体转阴。3名出生时母血HCMV-IgG阳性者中,1名婴儿IgA和‘gG转阳,此时母亲IgA也阳转。随访的16名婴儿中有3名可能是生后半年内受HCMV感染。
The detection of HCMV IgA antibody by ELISA was used to detect HCMV antibody in 100 maternal and infant babies in Beijing. The positive rates of HCMV-IgG antibody in mother’s blood, umbilical cord blood and breast milk were 100%, 75%, 75% %, And 38% respectively. The positive rates of HCMV-IgA antibody were 19%, 15% and 58% respectively. Six months later, six of them were followed up for 6 months. Five of them were negative in mother and umbilical cord blood. Antibody positive rotation. 8 were born mother, umbilical cord blood were positive, there is still a positive IgA and found that the two fingers of the liver ribs. The other 1 IgG persisted, while the other 6 infants turned negative. Three of the three mothers who were positive for HCMV-IgG at birth were immunized with IgA and ’gG’ and the mother also had positive IgA. Three of the 16 infants followed up may be infected with HCMV within six months after birth.