氨基糖苷类抗生素具有对革蓝氏阴性杆菌的广谱抗菌作用和可与多种抗生素配伍使用的特点 ,为临床上治疗各系统感染重要的抗菌药物。同时 ,这类药物也存在耳、肾毒性和细菌耐药的问题 ,使其使用受到限制。因此 ,提高疗效 ,减少不良反应的发生成为这类药物使用研究的重点。按照现 Aminoglycoside antibiotics have a broad-spectrum antibacterial effect against Gram-negative bacilli and can be used in combination with various antibiotics. It is an important antibacterial drug for clinically treating various systems. At the same time, these drugs also exist ear, nephrotoxicity and bacterial resistance problems, its use is limited. Therefore, to improve the efficacy and reduce the incidence of adverse reactions become the focus of such drug use research. Follow the present