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１３只麻醉开胸犬，分级缩窄冠状动脉左旋支，直到血流中断。临床分３组：对照组、冠心病（ＣＨＤ）组、急性心肌梗塞（ＡＭＩ）组。均测定血浆心钠素（ＡＮＰ）、内源性洋地黄样物质（ＥＤＬＳ）、醛固酮（Ａｌｄｏ）、血浆肾素活性（ＰＲＡ）、血管紧张素Ⅱ（ＡｎｇⅡ），动物实验还增加左心功能检测。结果显示，实验性冠状动脉血流（ＣＢＦ）减少时心功能进行性减退；肾素－血管紧张素－醛固酮系统（ＲＡＡＳ）激活；ＡＮＰ分泌增加；ＥＤＬＳ减少。ＡＭＩ患者早期ＲＡＡＳ激活，ＡＮＰ增加，ＥＤＬＳ无改变，恢复期ＡＮＰ降低而ＥＤＬＳ增加。探讨了血管活性物质变化和机制，以及ＡＭＩ时应用血管紧张素转换酶抑制剂及外源性ＡＮＰ的意义。
Thirteen anesthetized thoracotomy dogs were graded to narrow the left circumflex coronary artery until the blood flow was interrupted. Clinical divided into 3 groups: control group, coronary heart disease (CHD) group, acute myocardial infarction (AMI) group. Plasma ANP, EDLS, Aldo, PRA and AngⅡ were measured in both groups, and left ventricular function test was also performed in animal experiments . The results showed that heart function decreased progressively when experimental coronary blood flow (CBF) decreased; activation of RAAS; increased secretion of ANP; decreased EDLS. Early AMI patients with RAAS activation, ANP increased, EDLS no change, recovery ANP decreased while EDLS increased. The changes and mechanisms of vasoactive substances and the significance of angiotensin converting enzyme inhibitors and exogenous ANP in AMI were discussed.