金属硫蛋白(MTs)是一类小分子量蛋白质,与二价金属有高亲和性,广泛存在于生物界,富含半胱氨酸。近年来,MTs越来越受到医学界的重视,在许多肿瘤组织中都证实有MTs表达的上调,且与肿瘤的关系密切。目前多数学者认为MTs对肿瘤细胞的生长、转移、耐药起促进作用,预示着不良的预后。但也有不同的看法。 Metallothioneins (MTs) are a class of small molecular weight proteins that have high affinity for divalent metals and are widely present in the biological world and are rich in cysteine. In recent years, MTs have drawn more and more attention from the medical community, and MTs expression has been confirmed to be up-regulated in many tumor tissues and closely related to tumors. At present, most scholars believe that MTs can promote the growth, metastasis and drug resistance of tumor cells, which indicates the poor prognosis. But there are different opinions.