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目的观察双嘧达莫联合强的松治疗小儿肾病综合征的临床疗效及对肾功能、凝血系统的影响。方法选取小儿肾病综合征确诊患儿150例,随机分为观察组与对照组各75例,所有患儿均予支持治疗。在此基础上,对照组予醋酸泼尼松片治疗,观察组在对照组基础上加予双嘧达莫治疗。比较2组治疗效果、肾功能指标及凝血指标。结果观察组总有效率为90.67%,高于对照组的80.00%(P<0.05),2组治疗后肾功能指标均有所改善,观察组患儿BUN、Scr水平低于对照组,Ccr水平高于对照组(P<0.05)。治疗后2组PT、APTT均高于治疗前(P<0.05),但2组比较差异无统计学意义(P>0.05)。结论双嘧达莫联合强的松治疗小儿肾病综合征的临床疗效满意,可缓解水肿症状,提高完全缓解率,更可改善血液高凝状态,抑制肾小球微血栓形成,改善肾功能,值得临床推广应用。
Objective To observe the clinical effect of dipyridamole combined with prednisone on children with nephrotic syndrome and its effect on renal function and coagulation system. Methods 150 children diagnosed with nephrotic syndrome in children were randomly divided into observation group and control group, with 75 cases in each group. All children received supportive treatment. On this basis, the control group was treated with prednisone acetate tablets, and the observation group was treated with dipyridamole on the basis of the control group. The therapeutic effects, renal function indexes and coagulation indexes of the two groups were compared. Results The total effective rate in the observation group was 90.67%, which was higher than that in the control group (80.00%, P <0.05). The renal function indexes of the two groups were improved after treatment. The levels of BUN and Scr in the observation group were lower than those in the control group Higher than the control group (P <0.05). After treatment, the PT and APTT in both groups were significantly higher than those before treatment (P <0.05), but there was no significant difference between the two groups (P> 0.05). Conclusions Dipyridamole and prednisone are effective in treating nephrotic syndrome in children, which can relieve the symptoms of edema, improve the complete remission rate, improve the hypercoagulability of blood, inhibit the formation of glomerular microthrombus and improve the renal function. Clinical application.