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目的:考察注射用头孢西丁钠与注射用炎琥宁在0.9%氯化钠注射液中的配伍稳定性。方法:在20℃下采用RP-HPLC法测定注射用头孢西丁钠与注射用炎琥宁在0.9%氯化钠注射液中配伍后8 h内不同时间点的含量,并观察和检测配伍液的外观及pH变化。结果:在室温下配伍液8 h内的含量、pH及外观均无明显变化。结论:注射用头孢西丁钠与注射用炎琥宁20℃在0.9%氯化钠注射液中可在配伍后8 h内使用。
Objective: To investigate the compatibility of cefoxitin sodium for injection and injection of mesylate in 0.9% sodium chloride injection. Methods: The contents of cefoxitin sodium for injection and injection of mesylate in different time points within 8 h after 0.9% sodium chloride injection were determined by RP-HPLC at 20 ℃. Appearance and pH changes. Results: There was no significant change in the content and pH of the compatibility solution within 8 h at room temperature. CONCLUSION: Cefoxitin sodium for injection and injection of memantine 20 ℃ in 0.9% sodium chloride injection can be used within 8 h after compatibility.