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将 2 1只雄性大白兔随机等分成 3组 :环磷酰胺组 ( A组 )、动脉粥样硬化对照组 ( B组 )和正常对照组 ( C组 ) ,观察免疫抑制剂环磷酰胺对高脂血症动物的血脂、抗体、补体以及动脉粥样硬化 ( atherosclerosis,AS)病变的影响。实验结束时发现 :A、B两组的血脂、抗体、补体及循环免疫复合物 ( CIC)水平明显高于 C组 ;A、B两组血脂水平相比无明显差异 ,但免疫指标相比有明显差异 ;A组的主动脉斑块面积和主动脉内膜厚度明显小于 B组 ( P<0 .0 1)。本实验提示 AS的发生与免疫反应有关 ,环磷酰胺可以减轻兔主动脉粥样斑块的形成 ,但不是通过降血脂途径。
A total of 21 male rabbits were equally divided into three groups: cyclophosphamide group (A group), atherosclerosis control group (B group) and normal control group (C group). Immunosuppressive agents cyclophosphamide Effects of lipids, antibodies, complement, and atherosclerosis (AS) in hyperlipidemic animals. At the end of the experiment, the levels of serum lipids, antibodies, complement and circulating immune complex (CIC) in group A and group B were significantly higher than those in group C; There was no significant difference in blood lipid levels between group A and group B Significant difference; A group of aortic plaque area and aortic intimal thickness was significantly less than the B group (P <0.01). This experiment suggests that the occurrence of AS and immune response, cyclophosphamide can reduce rabbit aortic plaque formation, but not through the lipid-lowering pathway.