论文部分内容阅读
药物离子导入法虽已广泛应用于心血管疾病,但对β-肾上腺素能受体阻滞剂却没有采用过这种方法。作者研究了β-肾上腺阻滞化合物借助直流电导入的可能性和方法,先对心得安与心得静剂型的稳定性和迁移率的理化性质进行了研究,其方法是采用紫外线光谱分光光度测定法。测定结果表明,只有心得安剂型在直流电场中是稳定的和迁延的,心得静在此电场中被分解.又在动物实验中,研究了β-肾上腺阻滞剂离子导入对心率和心电图某些指数的影响。把32只体重2～2.5公斤的家兔分5组进行实验:第1组只注射异丙肾上腺素(以下简称异
Although the drug iontophoresis has been widely used in cardiovascular diseases, this method has not been used for β-adrenergic receptor blockers. The authors investigated the possibility and method of introduction of β-adrenal blocker compounds by direct current. The physicochemical properties of propranolol and propranolol stability and mobility were investigated by UV spectrophotometry. The results show that only the andener dosage form is stable and persistent in the DC electric field and the static is decomposed in this electric field.And in animal experiments, β-adrenoceptor iontophoresis has been studied for some of the heart rate and electrocardiogram The impact of the index. 32 rabbits weighing 2 ~ 2.5 kg were divided into 5 groups for experiment: group 1 was injected only with isoproterenol (hereinafter referred to as