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目的研究高压氧治疗糖尿病足发生医院感染的状况及感染病原菌的分布、耐药性,指导临床预防和治疗糖尿病足感染。方法选取2009-2012年在医院进行高压氧治疗的糖尿病足患者共335例,记录医院感染发生状况,研究感染的病原菌及耐药性,采用K-B琼脂法进行药敏试验。结果糖尿病足患者进行高压氧治疗后发生医院感染33例,感染率为9.85%;检出革兰阳性菌14株占33.33%,革兰阴性菌21株占50.00%,真菌7株占16.67%;主要革兰阳性菌对利奈唑胺和替考拉宁耐药率为0,革兰阴性菌对亚胺培南和阿米卡星耐药率均为10.00%;真菌对氟胞嘧啶和灰黄霉素耐药率为0。结论高压氧治疗糖尿病足的患者医院感染的发生率高,且多为耐药菌感染;临床应采取措施控制医院感染的发生,一旦感染发生分离培养病原菌采用耐药率低的抗菌药物进行治疗。
Objective To study the status of nosocomial infection of hyperlipidemia and the distribution of pathogenic bacteria and drug resistance in diabetic foot and to guide clinical prevention and treatment of diabetic foot infection. Methods A total of 335 diabetic patients with hyperbaric oxygen were selected from 2009 to 2012 in our hospital. The incidence of nosocomial infections was recorded. Pathogenic bacteria and drug resistance of the patients were recorded. K-B agar assay was used to determine drug susceptibility. Results Thirty-three cases of nosocomial infection were found after diabetic hyperbaric oxygen therapy. The infection rate was 9.85%. Among them, 14 strains of Gram-positive bacteria accounted for 33.33%, 21 strains of Gram-negative bacteria accounted for 50.00% and 7 strains accounted for 16.67% The main gram-positive bacteria to linezolid and teicoplanin resistance rate of 0, gram-negative bacteria resistant to imipenem and amikacin were 10.00%; fungi on flucytosine and gray The rate of drug resistance was 0. Conclusion The incidence of nosocomial infections in patients with diabetic foot treated with hyperbaric oxygen is high, and most of them are resistant to drug-resistant bacterial infections. Measures should be taken to control the occurrence of nosocomial infections in patients with hyperbaric oxygen therapy. Once the infection occurs, the pathogenic bacteria are isolated and treated with antimicrobial agents with low resistance rate.