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应用尿hGH免疫放射测定法,测定了12例成年男性、12例成年女性和17例肢端肥大症夜10小时尿hGH排泄量,分别为0.58±0.56ng,0.52~0.37ng和167.1±278.2ng。肢端肥大症夜10小时尿hGH排泄量显著高于正常人(P<<0.001),且无一例重叠。通过8例肢端肥大症上午8小时血清hGH谱与夜10小时尿hGH排泄量的观察,发现两者呈显著相关,提示夜晚和日间可能有相同的hGH分泌模式,尿hGH排泄量测定能够反映血清hGH分泌情况。提示,用本法测定尿hGH排泄量有助于诊断肢端肥大症。
Urine hGH immunoradioassay was used to determine urinary hGH excretion in 12 adult men, 12 adult women, and 17 cases of acromegaly at 10 hours of night, respectively, and were 0.58 ± 0.56 ng, 0.52 to 0.37 ng and 167.1 ± 278.2 ng, respectively . Acromegaly 10 hours urine hGH excretion was significantly higher than normal (P << 0.001), and no case of overlap. 8 h acromegaly 8 h morning serum hGH spectrum and 10 h urinary hGH excretion observed and found significant correlation between the two, suggesting that night and day may have the same hGH secretion patterns, urinary hGH excretion can be measured Reflect the secretion of serum hGH. Tip, using this method to determine urinary hGH excretion helps diagnose acromegaly.