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本文介绍了墨汁灌注、塑料灌注、扫描电镜观察及透射电镜观察等手段来研究肠道粘膜微循环的方法,并用这些方法观察了大鼠~(60)Co全身一次照射20GY后肠道微循环的改变。发现照后不同时期血管与粘膜有相应变化,血管先收缩,而后扩张,再收缩;血管口径粗细不一,照后24小时后改变更显著,绒毛上端血流中断,在扫描电镜下小肠绒毛血管网呈火山喷口式,血管断端呈鼓锤状。从透射电镜下可见血管口径数量改变的原因是内皮先有肿胀,而后有变性、坏死以及增生,终而可阻塞血管。血流中断与绒毛细胞上部脱落坏死并行。
In this paper, the methods of ink perfusion, plastic perfusion, scanning electron microscopy and transmission electron microscopy were introduced to study the intestinal mucosal microcirculation. The effects of 60Co on the intestinal microcirculation change. The changes of blood vessels and mucosa were observed at different periods after irradiation. The vessels contracted first, then dilated and then contracted. The diameters of blood vessels differed from each other. After 24 hours, the changes were more pronounced. The blood flow in the upper part of the villus was interrupted. Network was volcanic vents, blood vessels stump was drum-shaped. From the transmission electron microscope shows the number of vascular caliber changes due to endothelial first swelling, then degeneration, necrosis and hyperplasia, and finally can block the blood vessels. Blood flow interruption and villus cells fall off necrosis in parallel.