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多巴胺是一种内源性儿茶酚胺,主要药理作用有拟交感神经作用,包括心脏β_1-肾上腺能受体兴奋,使肾上腺素能神经末梢释放去甲肾上腺素;小剂量多巴胺可兴奋特殊“多巴胺”受体,这种作用与各种血管床的选择性血管扩张有关(包括肾动脉).多巴胺的药理作用可由酚噻嗪和氟哌啶醇阻滞,但不被β_1-肾上腺素受体阻滞药物阻滞.随着β_1受体阻滞剂在临床上的广泛应用,过量或中毒并不少见.现报道普萘洛尔和阿替洛尔过量中毒病人试用多巴胺抢救的体会.
Dopamine is an endogenous catecholaminergic and has the main pharmacological effects of sympathomimetic action including excitability of the cardiac β 1 -adrenoceptor and norepinephrine release from adrenergic nerve endings; This effect is associated with the selective vasodilatation of various vascular beds, including the renal arteries. The pharmacological effects of dopamine can be blocked by phenothiazine and haloperidol, but not by the beta 1 -adrenoceptor blocker Block.With the β_1 receptor blockers widely used in clinical practice, excessive or poisoning is not uncommon.Some reports of propranolol and atenolol in patients with excessive poisoning try to rescue the experience of dopamine.