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为探讨病毒性心肌炎（VMC）和扩张型心肌病（DCM）发病的自身免疫机制，采用酶联免疫吸附和放射免疫技术检测30例VMC、14例DCM患儿血浆中抗肌球蛋白抗体和粒细胞-巨噬细胞集落刺激因子（GM－CSF）。结果：VMC和DCM患儿抗肌球蛋白抗体和GM－CSF的阳性率均为54．5％（24／44），而正常对照组分别为4．0％（1／25）和8．0％（2／25）（均P＜0．01），且抗肌球蛋白抗体与GM－CSF的血浆水平有正相关性（r＝0．3583，P＜0．05）。提示：抗肌球蛋白抗体和GM－CSF均参与了VMC和DCM的发病，与心肌的自身免疫损伤过程有关。
To investigate the mechanism of autoimmunity in the pathogenesis of viral myocarditis (VMC) and dilated cardiomyopathy (DCM), 30 cases of VMCs and 14 cases of DCM were detected by enzyme-linked immunosorbent assay and radioimmunoassay. Anti-myosin antibody Cell-macrophage colony-stimulating factor (GM-CSF). Results: The positive rates of anti-myosin antibody and GM-CSF in VMC and DCM were 54.5% (24/44) and 4.0% (1/25) and 8.0 % (2/25) (all P <0.01), and there was a positive correlation between anti-myosin antibody and the plasma level of GM-CSF (r = 0.3583, P <0.05). Tip: anti-myosin antibody and GM-CSF are involved in the pathogenesis of VMC and DCM, and myocardial autoimmune damage process.