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目的硝苯地平联合拉贝洛尔治疗重度子痫前期的临床疗效。方法选取2012年1月—2014年2月石家庄市妇幼保健院收治的重度子痫前期患者96例,随机分为对照组(51例)和观察组(45例)。两组患者均给予常规护理及硫酸镁治疗,对照组患者予以硝苯地平治疗,观察组患者予以硝苯地平联合拉贝洛尔治疗。观察两组患者临床疗效、治疗前后血压(收缩压、舒张压)、妊娠延长时间、胎儿宫内窘迫、新生儿窒息、产后出血发生情况及不良反应发生情况。结果观察组患者临床疗效优于对照组,差异有统计学意义(P<0.05);治疗前两组患者收缩压、舒张压比较,差异无统计学意义(P>0.05),治疗后观察组患者收缩压、舒张压低于对照组,差异有统计学意义(P<0.05);观察组患者妊娠延长时间长于对照组,差异有统计学意义(P<0.05);观察组患者胎儿宫内窘迫、新生儿窒息发生率低于对照组,差异有统计学意义(P<0.05),两组患者产后出血发生率比较,差异无统计学意义(P>0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论硝苯地平联合拉贝洛尔治疗重度子痫前期的临床疗效显著,可降低患者血压,延长妊娠时间,减少胎儿窘迫及新生儿窒息的发生,不良反应小。
Objective Nifedipine combined with labetalol in the treatment of severe preeclampsia clinical curative effect. Methods Ninety-six patients with severe preeclampsia who were treated in Shijiazhuang MCH hospital from January 2012 to February 2014 were randomly divided into control group (n = 51) and observation group (n = 45). Both groups were given routine care and magnesium sulfate treatment, patients in the control group were treated with nifedipine, and patients in the observation group were treated with nifedipine and labetalol. The clinical efficacy, blood pressure (systolic blood pressure, diastolic blood pressure), prolongation of pregnancy, fetal distress, neonatal asphyxia, postpartum hemorrhage and adverse reactions were observed before and after treatment. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). There was no significant difference in systolic blood pressure and diastolic blood pressure between the two groups before treatment (P> 0.05). After treatment, the patients in the observation group Systolic blood pressure and diastolic blood pressure were lower than those in the control group (P <0.05). The prolongation of pregnancy in the observation group was longer than that in the control group (P <0.05). In the observation group, fetal distress, The incidence of asphyxia in children was lower than that in control group, the difference was statistically significant (P <0.05). There was no significant difference in the incidence of postpartum hemorrhage between the two groups (P> 0.05). The incidence of adverse reactions in both groups was significantly different No statistical significance (P> 0.05). Conclusion Nifedipine combined with labetalol is effective in treating severe preeclampsia. It can reduce the blood pressure, prolong the pregnancy time, reduce the fetal distress and neonatal asphyxia with little adverse reaction.