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野葛Pueraria lobata根茎中主要成分为葛根素和大豆黄苷等异黄酮。葛根素和大豆黄苷在人肠内微生物作用下可转化为大豆黄酮和毛蕊异黄酮。作者研究了葛根素、大豆黄苷及其肠内代谢物大豆黄酮等的抗过敏、抗血栓作用。抗血小板凝集的体外实验显示,葛根素、大豆黄苷和大豆黄酮对二磷酸腺苷(ADP)和胶原所致血小板凝集显示抑制作用,大豆黄酮的抑制活性最强,对ADP和胶原所致血小板凝集的IC_(50)分别为0.2和0.05mg/mL;在体内实验中,腹腔注射葛根素和大豆黄苷抑制血小板凝集的效果比口服用药效果差。对
The main components of Pueraria lobata rhizomes are isoflavones such as puerarin and daidzin. Puerarin and daidzein can be converted into daidzein and causal isoflavones by the action of microorganisms in the human intestine. The authors studied the antiallergic and antithrombotic effects of puerarin, daidzein, and its intestine metabolite daidzein. Anti-platelet agglutination in vitro experiments showed that puerarin, daidzein and daidzein showed inhibition of platelet aggregation induced by adenosine diphosphate (ADP) and collagen, and daidzein had the strongest inhibitory activity against platelets caused by ADP and collagen. The agglutinated IC 50 was 0.2 and 0.05 mg/mL, respectively; in vivo, puerarin and daidzein were less effective than oral administration in inhibiting platelet aggregation. Correct