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细胞黏附分子(CAMs)是一类介导细胞与细胞、细胞与细胞外基质间黏附作用的膜表面糖蛋白,参与细胞的生长分化、组织修复、肿瘤的侵袭与转移等。子宫内膜异位症(EMs)是育龄妇女的一种常见病,其发病机制不清。已证实CAMs是与EMs发病密切相关的一类分子,其通过调节异位内膜细胞与腹膜的黏附,参与异位内膜的种植。深入研究CAMs在EMs发病中的作用,对寻找生物治疗的靶点有重要临床意义。对两者的关系进行综述。
Cell adhesion molecules (CAMs) are a type of membrane surface glycoprotein that mediates adhesion between cells and cells, cells and extracellular matrix. They are involved in cell growth and differentiation, tissue repair, tumor invasion and metastasis. Endometriosis (EMs) is a common disease in women of childbearing age, its pathogenesis is unclear. It has been confirmed that CAMs are closely related to the pathogenesis of EMs, a class of molecules that regulate the adhesion of ectopic endometrial cells to the peritoneum and participate in the cultivation of ectopic endometrium. In-depth study of the role of CAMs in the pathogenesis of EMs is of great clinical significance in the search for targets of biological therapy. The relationship between the two is reviewed.