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目的 探讨胃癌组织中 β 连接素 ( β catenin)蛋白的表达及其与胃癌组织学特征和侵袭转移的关系。 方法 采用免疫组织化学ABC法检测 3 8例胃癌组织中 β catenin的表达。 结果 正常胃粘膜上皮细胞全部表达 β catenin ,胃癌组织中β catenin的表达率分别是“ +++”为 5 0 .0 % ( 19/3 8) ,“ ++”为 2 6.3 % ( 10 /3 8) ,“ +”为 2 3 .7% ( 9/3 8)。有淋巴结转移的胃癌组织中 β -catenin的表达率是“ +++”为 2 6.1% ( 6/2 3 ) ,显著低于无淋巴结转移者 (P <0 .0 1)。结论 β catenin的表达与胃癌组织学特征及侵袭转移有相关性 ,可以作为预测胃癌侵袭转移的有价值的指标。
Objective To investigate the expression of β-catenin in gastric carcinoma and its relationship with histological characteristics and invasion and metastasis of gastric carcinoma. Methods Immunohistochemical ABC method was used to detect the expression of β catenin in 38 cases of gastric cancer. Results The normal gastric mucosal epithelial cells expressed β catenin, the expression rates of β catenin in gastric cancer tissues were 50.0% (19/3 8) for +++ and 23.3% (++) 3 8), “+” is 23.7% (9/3 8). The expression of β-catenin in gastric cancer with lymph node metastasis was 23.1% (6/2 3) for +++, which was significantly lower than that for those without lymph node metastasis (P <0.01). Conclusions The expression of β catenin is correlated with the histological characteristics and invasion and metastasis of gastric cancer, which may be used as a valuable index in predicting the invasion and metastasis of gastric cancer.